7-Amino-3-cephem-4-carboxylic acid
Cov ntaub ntawv tseem ceeb:
English npe:
7-ANCA;7-AMOCA;(6R,7R)-7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicAcid;7-NACA;7- NACA,7-ANCA; 7-ANCAChemicalbookimpurity; CeftizoximeImpurity9; CeftizoximeImpurity16; Ceftizoximeintermediate(7-anca); 7-amino-3-cephem-4-carboxylicacid
CAS Nr .: 36923-17-8
Cov mis mos molecular: C7H8N2O3S
Molecular Luj: 200.21
PIB: 609-312-7
Tus qauv qauv:
Yam khoom muaj feem: Organic intermediates; Pharmaceutical intermediates; Pharmaceutical raw khoom.
Melting point: 215-218 ° C
Kub taw tes: 536.9 ± 50.0 ° C (Predicted)
Ceev: 1.69 ± 0.1g / cm3 (Predicted)
Refractive Index: 1.735 (kwv yees)
Lub teeb taw tes: 278.508 ° C
Solubility: Soluble nyob rau hauv acidic aqueous tov (me ntsis, rhuab), DMSO (me ntsis). Khoom: Dawb los yog dawb crystalline hmoov.
Vapor siab: 0mmHg ntawm 25 ° C
| specification | chav tsev | txheem |
| Qhov tshwm sim | Dawb los yog dawb crystalline hmoov | |
| Cov ntsiab lus tseem ceeb | % | ≥98.5% |
| Moisture | % | ≤1 |
| Mono hybrid | % | ≤0.5 |
| Tag nrho clutter | % | ≤1 |
Cephalosporin, siv los ua ib qho nruab nrab ntawm cefbutan thiab cefazoxime.
Concentrated sulfuric acid (104.3mL, 1.92mol) tau ntxiv rau hauv peb lub raj mis, tom qab ntawd isophthalic acid (40g, 0.24mol) ntxiv, nplawm thiab rhaub rau 60 ℃, tuav rau 0.5h, thiab 60% nitric acid (37.8g, 0.36). mol) tau ntxiv los tswj qhov kev ua kom nrawm nrawm. Ntxiv nws hauv 2 teev. Tom qab ntxiv, cov tshuaj tiv thaiv tshav kub ntawm 60 ℃ rau 2 teev. Txias kom qis dua 50 ° C, tom qab ntawd ntxiv 100mL dej. Cov khoom siv tau txias rau hauv chav tsev kub, nchuav rau hauv lub lim, tso tawm kom tshem tawm cov kua qaub pov tseg, lim ncuav mog qab zib yog ntxuav nrog dej, drained rau recrystallize, thiab cov khoom dawb yog 34.6 grams, yield yog 68.4%.
20Kg lossis 25Kg / thoob, thawv ntawv, kab nrog ib txheej dawb thiab ib lub hnab dub polyethylene. 2 ℃ -8 ℃ qhuav, qhov chaw txias, deb ntawm lub teeb cia, siv tau rau 2 xyoos.
