Sulfadiazine sodium yog tshuaj tua kab mob nruab nrab sulfonamide uas muaj cov kab mob tua kab mob ntawm ntau cov kab mob Gram-positive thiab Gram-negative. Nws muaj cov tshuaj tua kab mob ntawm cov tsis-enzyme-tsim Staphylococcus aureus, Streptococcus pyogenes, Streptococcus pneumoniae, Escherichia coli, Klebsiella, Salmonella, Shigella, Neisseria gonorrhoeae, Neisseria meningitidis, thiab Haemophilus influenzae. Tsis tas li ntawd, nws tseem muaj zog tiv thaiv Chlamydia trachomatis, Nocardia asteroides, Plasmodium, thiab Toxoplasma hauv vitro. Cov tshuaj tua kab mob ntawm cov khoom no yog tib yam li sulfamethoxazole. Txawm li cas los xij, nyob rau xyoo tas los no, cov kab mob ua rau cov khoom no tau nce ntxiv, tshwj xeeb tshaj yog Streptococcus, Neisseria, thiab Enterobacteriaceae.