Sulfamethazine

Sulfadiazine yog ib qho tshuaj tua kab mob sulfanilamide nrog cov tshuaj tua kab mob zoo sib xws rau sulfadiazine. Nws muaj cov tshuaj tua kab mob ntawm cov kab mob enterobacteriaceae xws li cov kab mob uas tsis yog-zymogenic Staphylococcus aureus, Streptococcus pyogenes, Streptococcus pneumoniae, Escherichia coli, Klebsiella, Salmonella, Shigella, thiab lwm yam. Txawm li cas los xij, cov kab mob ua rau cov khoom lag luam nce ntxiv, tshwj xeeb tshaj yog cov kab mob streptococcus, Neisseria thiab Enterobacteriaceae kab mob. Sulfonamides yog broad-spectrum bacteriostatic agents, zoo ib yam nyob rau hauv cov qauv rau p-aminobenzoic acid (PABA), uas muaj peev xwm sib tw ntawm dihydrofolate synthetase nyob rau hauv cov kab mob, yog li tiv thaiv PABA los ntawm kev siv raws li raw khoom los ua ke folate xav tau los ntawm cov kab mob thiab txo tus nqi ntawm metabolically active tetrahydrofolate. Cov tom kawg yog ib yam khoom tseem ceeb rau kev sib txuas ntawm purines, thymidine nucleosides thiab deoxyribonucleic acid (DNA), yog li nws inhibits kev loj hlob thiab kev loj hlob ntawm cov kab mob.